DTRA, DOMANE, and Remdesivir
FEB, 2021: Defense Threat Reduction Agency "Latches on" to Remdesivir using DOMANE computer modeling. Separate article claims that Dr. Robert Malone was a consultant on the DTRA DOMANE project.
FORT BELVOIR, VA, UNITED STATES
Story by Darnell Gardner
Defense Threat Reduction Agency
FORT BELVOIR, Va. - The COVID pandemic took the world by surprise. Researchers were left scrambling to devise a way to best mitigate the negative impact this disease has on global health. However, at the Defense Threat Reduction Agency (DTRA) it is common to operate in the “what if” space when it comes to potential biological threats. In fact, DTRA investments in technologies that detect, mitigate, or neutralize chemical and biological threats to the military and the nation date back more than 20 years.
“In late 2019, DTRA started a new program called Discovery of Medical Countermeasures Against Novel Entities (DOMANE) to address novel and emerging threats,” stated Dr. David Hone, Chief Scientist within the Vaccines and Therapeutics Division at DTRA. “Based on previous work, we decided DOMANE would not only focus on FDA-approved drugs but also combination therapeutics, as we believe that no single drug will be completely effective in treating new diseases. COVID-19 has provided us an opportunity to test our hypotheses using DOMANE.”
DOMANE provides rapid decision-making capabilities to identify FDA-approved drugs that will most likely be effective therapeutics for COVID-19. Repurposing candidate drugs from a pool about 7,500 FDA-approved drugs to advance an effective COVID-19 therapeutic allows for a more rapid response in developing a therapeutic regimen. The end-result is a response that modifies COVID-19 in treated patients and promotes a speedy recovery.
Sage comments: A speedy recovery?
Do you mean…kills them quickly?
Also, isn’t it interesting that Ivermectin did not make the cut in this special fancy DOMANE system?
Veklury®, which is more commonly referred to as Remdesivir, is a ribonuclease inhibitor developed by Gilead Sciences. It delivers broad-spectrum antiviral activity and has proven to be a modestly effective therapeutic for the treatment of COVID-19. Originally developed as an Ebola Zaire countermeasure, this DTRA-funded inhibitor transitioned for more advanced testing due to promising pre-clinical trials. Remdesivir inhibits viral replication in a wide variety of pathogens and was one of the first therapeutics identified in the Defense Department for repurposing to treat COVID-19. In the summer of 2020, Remdesivir received authorization for emergency use only in COVID-19 patients with continued FDA oversight.
Sage: Are you clocking this? “DTRA-funded inhibitor”?
Also, again for emphasis:
Remdesivir inhibits viral replication in a wide variety of pathogens and was one of the first therapeutics identified in the Defense Department for repurposing to treat COVID-19.
Sounds like the Defense Department didn’t get the Run, Death is Near, memo.
Or actually, they did.
To complement the modest therapeutic effect of Remdesivir, DOMANE also identified Famotidine, a COVID-19 disease modifier from Johnson & Johnson; Pfizer’s Celecoxib, an anti-inflammatory product; and Merck’s Mectizan®, Ivermectin, an antiviral for clinical trials. To learn whether a combination of these FDA-approved drugs is more efficacious than current treatments, DTRA partnered with Quantum Leap Healthcare to conduct a clinical trial. This volunteer trial will evaluate drug combinations in COVID-19 patients who are having difficulty breathing.
Sage: From Robert Malone’s J’Accuse post:
And not long after that I dropped off. Which is a shame, because the reason I was there was to help get our fully powered, innovative inpatient and outpatient trials of the repurposed drugs famotidine, celecoxib, and ivermectin launched under DoD/DTRA funding which I had worked so hard to get dedicated to this project.
Sage: I’m just going to point out the obvious omission here.
But DTRA did fund, per this article, and “latched on to”…Remdesivir.
Is it odd that Doc Malone would not specifically call out DTRA and hammer them for this?
Kind of a giant elephant in the room to not acknowledge.
In journalism, we might call this….“burying the lede”, or more accurately, “avoiding the lede altogether”. 🧐
A better example of burying the lede is what I’m doing in this post.
Meta! Lede incoming.
I am about to post a video on Remdesivir from early 2021.
Remdesivir is a dangerous herd culling, DTRA/DOMANE selected drug designed to
kill people “treat” COVID, and along the way make a fortune for Gilead Sciences.
I am looking into whether a prominent individual was also integrally involved with DOMANE, (and Dr. David Hone) and the computer system designed to steer DTRA towards certain drugs such as Remdesivir to treat *novel viruses.
*wink-wink* You never know when one of those novel viruses might catch you by surprise!
But this article from Silicon Icarus indicates that The Most Interesting Guy in the World may have been part of the DOMANE team.
If so, it would be interesting to get a glimpse behind the curtain, would it not?
Simultaneously in the U.S., it is claimed, an old colleague of Callahan’s Dr. Robert Malone had been conducting a study with U.S. government-sponsored research teams. Specifically, Malone was working alongside U.S. Defense Threat Reduction Agency (DTRA) consultants to carry out supercomputer-based analyses to identify existing FDA-approved drugs that may be useful against the novel coronavirus responsible for COVID-19. Per their analyses, famotidine turned out to be the “most attractive combination of safety, cost and pharmaceutical characteristics“.
Let’s go back to our DTRA article.
DTRA also collaborated with Leidos to develop a new clinical trial prototype to evaluate new drug combinations in two clinical studies: one in COVID-19 patients who have symptoms but are still breathing without assistance and another in COVID-19 that are not displaying any symptoms.
“We believe that the evaluation of additional repurposed drugs in clinical trials will find a successful treatment option and will pave the road toward FDA-approval of a greatly improved therapeutic treatment for COVID-19 patients,” said Hone.
DTRA is committed to supporting global health biosecurity efforts through continued vaccine and therapeutic discovery actions to treat COVID-19, as well as the next biological threat the nation faces.
Sage: Of course you are DTRA. Of course you are.
The Defense Threat Reduction Agency enables the Department of Defense, the United States government, and international partners to counter and deter weapons of mass destruction and improvised threat networks. For more information, visit https://www.dtra.mil.
*Did a little bonus stacking and went ahead and sourced an article that purports that Dr. Robert Malone was involved with DOMANE*
Would be very interesting to hear more about his time consulting with DTRA and if he did work on DOMANE to hear how Remdesivir made it onto the therapeutics list.
He could write a Substack about it.
Remdesivir - oh, u have covid, go home and wait until you can't breath. We will have ventilators and Remdesivir waiting for you to end your struggle with covid (finishing you off so we can be paid for covid patients.)