Previously on Infectious Clones Made Easy, we learned that Viral Swarms in Nature are bunglers creating duds and variants, and thus are probably not Herd Culling Pandemic capable; primarily because their RNA replication is not high fidelity enough to consistently manufacture the killers.
In a nutshell, Natural RNA Viral Swarms are Dolts Botching Shit.
“the majority are…replication incompetent, they’re useless.”
(Time code, 45:17, pix are linked to JJ Couey Twitch video class, scrub to time codes as listed.)
My homie Dr. Flurm questions the relative weak sauce magnitude of the Natural Swarm Dolts Botching Shit premise, fine.
But we are getting ahead of ourselves with pushback.
My intent here with this series is to break down JJ Couey’s paradigm into Shih Tzu speak so that we have a building block basis to understand, discuss, and prosecute the case further.
Because one thing I do know. The case is not going away.
The Green Team
What the Mad Scientists do is isolate a simple and abbreviated chain of DNA and ligate all this together like Demented Sociopaths to create a Gain of Purity Frankenvirus Swarm which does have Herd Culling Pandemic Potential, if only for a limited run.
Like a limited time frame set of Herd Culling Action Figures from McGacy’s with your Happy Meal.
Collect them all!
When you cough out a Natural Swarm virus, only a few are Replication Competent. As such, it is also very difficult to grow these Bungler Virus particles in a Petri dish. They just don’t replicate very well.
The Green Team is different.
The Green Team are the Infectious Clones. A lab made wrecking crew.
Say your Herd Culling Eco Health funded Mad Scientist finds a novel Spike protein in the wild.
Yay! says Ralph. Let’s just call HCEHMS Ralph. 😅
Let’s get to work!
Find five circular strands of DNA (cDNA) all of which have gene replicating capability.
cDNA is useful for the Herd Cullers because it can be replicated in bacteria. The Ralphs can grow huge colonies of bacteria, and by adding the cDNA into these cultures, the bacterial division will also create lots of cDNA, copied pretty flawlessly.
Bacterial Colonies help replicate the cDNA hitters. Bastards.
Do you think the Bacterial Colonies were signing up for work in the lab to cull the world? Probably not! They were probably like, “Yeah, I gotta go over to UNC and do some of that division stuff and what? Why are you putting this cDNA in me, guys?”
😹
Now you have a useful, reliable set of five Replication Competent cDNA strands to ligate together. (Five because it can’t get too large or it gets less effective. You need a small, competent team.)
Like a demented game of Tetris, Ralph fits the pieces of Hitter cDNA together.
And then fits the novel Spike protein into Slot #6.
A scientist out there probably just got very annoyed with me. 😅
(The Not a Virus crew is already on the horn with the Black Suburbans creating an anti-Sage Alliance. My days are numbered.)
Also, one of these days I should discuss the curious “memory” effect that I have personally experienced playing Tetris. As one part of my brain is tied up fitting blocks together, another part of my brain seems to flow freely and I am suddenly transported, vividly, viscerally remembering that day on the playground in second grade, the sun was shining, I can see the ashphalt. In high fidelity, like a High Fidelity Frankenvirus.
This high fidelity Tetris Frankenvirus tangent was brought to you by Cool Ranch Doritos.
I have now lost complete control over my post. Need coffee.
So anyway, the Ralphs create massive cultures of Bacteria laced with Hitter cDNA and then go about lysing the bacteria, or exploding them with detergent.
And also use a combination of techniques such as centrifugation and smart bombs (I made that one up) to get rid of the bacteria, and voila! Now you have a giant cDNA hitter pile of Viral Killers.
I have to go have some coffee now.
We’ll do more on this soon!
Also, I need a quality spiral notebook like that one JJ is using for my training log.
‘So anyway, the Ralphs create massive cultures of Bacteria laced with Hitter cDNA and then go about lysing the bacteria, or exploding them with detergent.’
Awww. A hitters first bath. Adorable. Ralphie Bear loves his little hitters.
Yo homes! Chimichangas!
So Re: DBS weak sauce. I generally agree with JJC — but I think if a natural RNA virus were as completely DBS replication incompetent though we would not have rna virus swarms around with us to give us colds and flu and even run of the mill coronavirus. Yes insert nadavirii here, etc. etc.
There’s a set of parameters thats going to affect how this thing proceeds — there’s some factor for the stability of the natural reproduction process. How like the parent is the child? Is it 5%? Is it 10%? 50%? 80%? Probably vastly different dynamics depending. There’s some factor I think in the fidelity direction coming from the swarm, probably reinforcing shared genetic motifs. The swarm I’m guessing adds reproductive benefit. I think where a DNA virus has its own backup copy, the ensemble of the swarm also provides some kind of backup copy. The operative unit is not a single virus particle, but the collection across the (how many? millions? billions?) of distributed sorts of particles within that swarm.
There’s also the chance that the replication of each just fails and the thing you make is like a pinto with two wheels and no roof. Or 17 wheels and no motor. DBS bastard pinto replication. Is that 5%? 50%? 80%? For a natural viral swarm I’m going to guess its actually pretty robust or they would have gone extinct billions of years ago.
Because they’re in an equilibrium. That’s the key
The green spikey guys aren’t anywhere near equilibrium, because we cooked them up, and to invoke the highly paraphrased quote I’m attributing to my vague rna DBS memory of a DarkHorse podcast somewhere, “It has not benefitted from passing through natural selection”. And also hasn’t reached a stable state.
So OK you release the pure green guys out and they start doing their some percent of DBS replication. And on top of that its probably worse, because they were built in a happy lab, with conditions tuned to make them work sorta good enough in a petri dish, but now you’ve thrown them into someone’s body full of snot, blood, all kinds of messy salty ionic substances. So there I agree its not gonna go well. But for how long? Must not be terribly bad because they can let this stuff loose in mice and see them get sick in a causal sort of way. Do they manage to keep it propagating mouse to mouse well?
But I think also there are plenty of the natural swarms floating around when this gets let loose, and probably they can intermingle bits and pieces of their songs between each other. But the result is the green guys get their sword edges dulled over time.
So maybe that fits what we’ve seen. Early on, in specific places they let loose some pure green guys somehow. I’m going to suggest its via that white powder inside whoopie cushions.
So then that gets out there and the first bunch of people get whalloped, since its the straight up green spikey bioweapon. But then that starts to degrade (fast? slow? depends on parameters like I said above) And then it hooks up with the local coronaviruses and they dance around. Eventually a new kind of equilibrium gets reached. Maybe that new equilibrium swarm has some variation of the green spikey guys leftover in it. Have we reached that? Maybe? No idea? They releasing green guys in 2019, then another purple set in 2021 then? Or is that what every wave has been?
Lots of stuff to think about in this. He seems to get to a place though where the actual viral infection is a minor component of all this. I don’t think we can say yet until stripping off the layers of comorbidities, lockdown neglect, medical mistreatment, transfection shitfuckery, etc. VERY interesting line of thinking.