Loa Loa and the Magic Merck Sauce
The Ivermectin Files, cont'd. September, 2000 Published Lancet study, long, long before the "You are Not a Horse"/World Ivermectin Day Psy Op
Summary (2000)
For many years, ivermectin has been widely distributed throughout west Africa for the *safe and effective control of onchocerciasis. However, recent events in Loa-loa-endemic areas of Cameroon, where severe adverse reactions have occurred, now constrain the public-health use of this drug in the forest habitat of the L loa vector. We have created a model of L loa prevalence to identify areas where high endemicity may be associated with the occurrence of such reactions. The model results have been mapped and the areas of overlap between high L loa prevalence and planned ivermectin distribution for onchocerciasis control identified.
*SAFE AND EFFECTIVE
However, recent events in Loa-loa-endemic areas of Cameroon, where severe adverse reactions have occurred, now constrain the public-health use of this drug in the forest habitat of the L loa vector.
It’s all safe and effective…
Until it’s not.
👇
Off to Spookipedia we go for the CIA’s take on all things Loa loa.
Loa loa
For the disease, see Loa loa filariasis.
Loa loa
Loa loa microfilaria found in blood film.
(Giemsa stain)Scientific classification
Domain:EukaryotaKingdom:AnimaliaPhylum:NematodaClass:ChromadoreaOrder:RhabditidaFamily:OnchocercidaeGenus:LoaSpecies:
L. loa
Binomial nameLoa loa
(Cobbold, 1864)
Dracunculus loa Cobbold, 1864[1]
Filaria loa (Cobbold, 1864)
Loa loa is a filarial (arthropod-borne) nematode (roundworm) that causes Loa loa filariasis. Loa loa actually means "worm worm", but is commonly known as the "eye worm", as it localizes to the conjunctiva of the eye. Loa loa is commonly found in Africa.[2] It mainly inhabits rain forests in West Africa and has native origins in Ethiopia.[3] The disease caused by Loa loa is called loiasis and is one of the neglected tropical diseases.[4]
L. loa is one of three parasitic filarial nematodes that cause subcutaneous filariasis in humans. The other two are Mansonella streptocerca and Onchocerca volvulus (causes river blindness).
Maturing larvae and adults of the "eye worm" occupy the subcutaneous layer of the skin – the fat layer – of humans, causing disease. The L. loa adult worm which travels under the skin can survive up to 10–15 years, causing inflammations known as Calabar swellings. The adult worm travels under the skin, where the female deposits the microfilariae which can develop in the host’s blood within 5 to 6 months and can survive up to 17 years. The young larvae, or microfilariae, develop in horseflies of the genus Chrysops (deer flies, yellow flies), including the species C. dimidiata and C. silacea, which infect humans by biting them. After bites from these infected flies, the microfilariae are unique in that they travel in the peripheral blood during the day and migrate into the lungs at night.[5]
At some point, may look into this deer flies, yellow flies thing, but who the heck knows? Maybe the mosquitoes in Brazil did in fact cause dengue and a Zika Virus Pandemic and associated birth defects.
Maybe DDT does in fact cure polio, too.
Treatment
Adult worms found in the eye can be surgically removed with forceps after being paralyzed with a topical anesthesia. The worm is not paralyzed completely, so if it is not extracted quickly, it can vanish upon attempting extraction.
Ivermectin has become the most common antiparasitic agent used worldwide, but can lead to residual microfilarial load when given in the management of loiasis. Treatment with ivermectin has shown to produce severe adverse neurological consequences in some cases. These treatment complications can be increased in individuals co-infected with onchocerciasis. Some of these patients experienced cases of coma and resultant encephalopathy, parkinsonism, and death. After about 12 hours, the first signs start to appear and include fatigue, pain in joints, mutism, and incontinence. Severe disorders of the consciousness start to develop after about a day.
Okay, so it’s Spookipedia, right?
They are blathering about neurological consequences and stuff about the Merck Mectin Sauce which the United States and Public Private Partners have been sending billions of doses down to the poors to save them.
Whatever.
😮
Back to Spookipedia.
Although Ivermectin is a common treatment for loiasis, the Centers for Disease Control (CDC) recommends treatment with diethylcarbamazine (DEC). Symptoms may be resolved with as little as 1–2 courses of DEC. DEC is chosen over Ivermectin because evidence supports its ability to kill both the adult worms and the microfilariae, which are the main cause of the severe neurological problems mentioned above. In some cases, albendazole may also be an effective treatment used to reduce the microfilariae prior to treatment with DEC. The body's response to albendazole is slow, so the patient being treated must be monitored closely and frequently to ensure it is effective.[14]
F-it, Spookipedia.
I’m going to the THE SCIENCE in 2003, long before the Covid Psy Op and the demonization of Petmectin.
2003 Pub Med
Abstract
The macrocyclic lactone ivermectin (Mectizan(R)) is widely used for the control of human filarial infections, particularly as a donated product for onchocerciasis and lymphatic filariasis.
In the case of control of lymphatic filariasis in Africa, it is used in combination with donated albendazole. In areas co-endemic for Onchocerciasis and Loa loa, serious adverse reactions have been observed in patients with apparently high microfilaria counts of Loa loa. Recent findings suggest that the severe central nervous system side effects seen in various vertebrates following ivermectin treatment may be due to an absence of, or functional deficiency in P-glycoprotein.
P-glycoprotein is expressed in the apical membrane of brain capillary epithelial cells and is responsible for limiting the brain penetration of a range of compounds. Toxicity of ivermectin in some collie dogs may be explained by a 4-bp deletion mutation of the mdr1 gene resulting in a frame shift, generating stop codons that prematurely terminate synthesis of P-glycoprotein. Additionally, sub-populations of CF-1 identified as expressing reduced levels of P-glycoprotein exhibit increased toxicity to substrates of this transporter.
Furthermore, while the traditional view of drug-drug interactions is alteration in drug clearance mediated through a change in hepatic drug metabolism, some of these changes may arise through competition for binding sites on P-glycoprotein in the blood-brain barrier, resulting in reduced extracellular efflux and enhanced CNS toxicity.
In conclusion, P-glycoprotein is an integral component of the human blood brain barrier and plays a central role in limiting drug uptake into the brain. Altered expression or function of p-glycoprotein could conceivably allow elevation of brain concentrations of ivermectin and produce severe neurotoxicity. This might arise through a genetic polymorphism in p-glycoprotein or co-administration of ivermectin with a drug or foodstuff that might inhibit this efflux transporter.
Okay.
I am far more likely to trust the animal studies than the hoooman critter studies because people do love their pets and the Owners who wish to cull the herd of hooomanz may not be as vigilant at falsifying the science.
Remember when I told you that what could heal could harm.
No?
What can heal can harm.
Dual use.
Ostensible Reason vs. Real Reason.
I’m going to leave it here for now and let you all dive in and discuss.
Two Three gut out in front of the brain hunches:
This P-glycoprotein angle is what the Scorpions like about IVM, me thinks.
There will be a drug synergy effect, exacerbated by regular “prophylactic” dosing of a synthetic drug modeled on nature, esp. b/c the Mectin likes to hang out in the fat cells.
The “flush” of foreign compounds out of cells that PgP provides will be flipped as a negative to STOP THE CANCER (and ??? not stop the host’s own flush mechanism?)
This efflux (flush out, pump) defense protein is the one that they want to inhibit in the Cancer Cells so the HEALING CHEMOTHERAPY drugs can stay in and tackle multi-drug resistance.
From a Progesterone Study, which is something that Promo Code Conspiracy Sarah immediately sensed…progesterone is birth control pills, widely widely taken.
Progesterone is also an apparent PGP inhibitor.
Abstract
P-Glycoprotein (P-GP) plays a pivotal role in maintaining the multidrug-resistant (MDR) phenotype. This membrane glycoprotein is overproduced in MDR cells and the endometrium of the mouse gravid uterus (Arceci, R. J., Croop, J. M., Horwitz, S. B., and Housman, D. (1988) Proc. Natl. Acad. Sei. U. S. A. 85, 4350–4354).
This latter observation and an interest in endogenous substrates for P-GP led to a study of the interaction of steroids with P-GP found in the endometrium of the mouse gravid uterus and in MDR cells derived from the murine macrophage-like cell J774.2. [³H]Azidopine labeling of P-GP from these two sources was inhibited by various steroids, particularly progesterone.
Progesterone also markedly inhibited [³H]vinblastine binding to membrane vesicles prepared from MDR cells, enhanced vinblastine accumulation in MDR cells, and increased the sensitivity of MDR cells to vinblastine. In addition, we have demonstrated that the hydrophobicity of a steroid is important in determining its effect on inhibition of drug binding to P-GP. It is concluded that progesterone, a relatively nontoxic endogenous steroid, interacts with P-GP and is capable of reversing drug resistance in MDR cells.
Okay.
Ready for some Ostensible Reasoning?
Effective cancer chemotherapy can be hindered by the acquisition of drug resistance in tumor cells. The molecular mechanisms underlying drug resistance are known to be di-verse(1).
One type of resistance that is being studied extensively in tumor-derived tissue culture systems and may be important in human tumors is multidrug resistance (MDR)’
(2-4). MDR cells, when selected for resistance to a single lipophilic agent such as vinblastine (VBL), develop resistance to a variety of structurally and functionally unrelated hydro-phobic drugs. An increasing body of evidence has suggested that in MDR cells, an overproduced plasma membrane glycoprotein, known as P-glycoprotein (P-GP), acts as a drug efflux pump to maintain drug concentrations below cytotoxic levels. Since P-GP plays a central role in MDR, and the mRNA coding for P-GP is overexpressed in some human tumors efforts have been made to identify drugs which interact with P-GP. Extensive studies have been done with verapamil(6-10) and other compounds (11-17) to investigate…
I find it fascinating that the Aussie Team that first "isolated" SARS-COV2 in January, 2020 immediately jumped on an Ivermectin study which "eliminated" the virus in cell culture
“As the virologist who was part of the team who were first to isolate and share SARS-COV2 outside of China in January 2020, I am excited about the prospect of Ivermectin being used as a potential drug against COVID-19,” Dr Caly said. Away we go. How did I get down this rabbit hole?
I do not believe that the Depopulation Owners of the World wish to cure cancer.
Cancer is a monster industry and the Day Tapes are explicit that they could already do so back in 1969.
“You may as well die of cancer as anything else.”
They want to keep this going at all costs. They are giving cancer to the world.
They want to exploit this P-Glycoprotein mutation.
They want to preserve the CHEMOTHERAPY DRUGS and other Pharmaceuticals just need to be able to overcome MULTI-DRUG RESISTANCE.
They want to kill you softly.
Of course, Elon.
Of course, McCullough. 👍
P-Glycoprotein genetic mutation in dogs.
Start digging into the many many cancer studies with IVM. Going way back before the purported novel virus.
What they are looking at.
Check out the IVM Good Team that got WAY WAY OUT IN FRONT of the novel coronavirus, *isolating* it and then they immediately dropped that shit into a cell culture and “found” that IVM killed New Mean Virus in Cell Culture.
Find out what else they are looking into.
Histone-mediated transduction as an efficient means for gene delivery
APR 16
Promo Code: Flurmie https://pubmed.ncbi.nlm.nih.gov/17327830/ Abstract Gene delivery into the nucleus of eukaryotic cells is inefficient, largely because of the significant barriers within the target cell of the plasma membrane and nuclear envelope. Recently, a group of basic proteins, including the HIV-1 Tat protein and the four core histones, have been s…
I’m asking you all to start digging into this.
The timeline is very fast. Very fast.
"Henry Kissinger's Depopulation list of Nations is Suspiciously Similar to Merck and Gates's Ivermectin "Donation" program list of Nations"
Whoa.
Hanna red that one yet, but thatz some SERIOUS dot connection, if accurate.
Floored.
Heinz.
The evil, poison toad.
No disrespect to the virtuous dead.
Saw somewhere today (can’t find it but it’s on Spookepedia) that the Brits in 1939 killed 400,000 pet dogs and cats (on recommendation of the govt) because of the threat of food shortages. Petmectin hadn’t been discovered yet I guess.