Research Dump Wednesday: Teratology, P-glycoproteins, Zika, Ivermectin...The Mind Begins to Spin
P-glycoprotein is an important protein of the cell membranes that pumps many foreign substances out of cells. (Guess where this is going...) *Not a Rando Friendly post with Goodies and Baddies*
Apology in advance.
I am sorry that this post is not a tidy summary of herd culling medical research but rather a jumbled and complicated presentation of various schemas in my brain all bumping into each other like Schema Bumper Cars at Shih-Tzu Arcade.
That made no sense.
We hooomanz do seem to desperately need narratives and stories and characters and heroes and villains. And on that note, I do not think that all the ice cubed Science and their Dutifully Funded Big Brainz exactly have any clue about what they are even doing.
(This is probably way way worse with the Engineer set currently figuring out how to make Digital Twins of Hoooommmaaannz.)
It may be beneficial for an outsider to examine and present.
(Some of those Scientists know full well, I’m sure, too.)
Chapter One: Teratology, Zika, Semen Counts
Teratology is the study of abnormalities of physiological development in organisms during their life span
Teratology
Teratology is the study of abnormalities of physiological development in organisms during their life span. It is a sub-discipline in medical genetics which focuses on the classification of congenital abnormalities in *dysmorphology caused by teratogens. Teratogens are substances that may cause non-heritable birth defects via a toxic effect on an embryo or fetus.
*A dysmorphic feature is an abnormal difference in body structure. It can be an isolated finding in an otherwise normal individual, or it can be related to a congenital disorder, genetic syndrome or birth defect.
Multiple dysmorphic features in a patient with Pitt–Rogers–Danks syndrome: microcephalia, micrognathia and protrusion of the eyeballs
Defects include malformations, disruptions, deformations, and dysplasia that may cause stunted growth, delayed mental development, or other congenital disorders that lack structural malformations.
The related term developmental toxicity includes all manifestations of abnormal development that are caused by environmental insult.
The extent to which teratogens will impact an embryo is dependent on several factors, such as how long the embryo has been exposed, the stage of development the embryo was in when exposed, the genetic makeup of the embryo, and the transfer rate of the teratogen.
Teratology sounds like it overlays with some dark eugenics research which I could probably find and have some nightmares about, but the first thing that I connected was the purported effects of the alleged Zika Virus which allegedly caused a pandemic and allegedly comes from mosquitoes of which Bill Gates and the WHO, et. al. would very much like to protect you with countermeasures and vaccines.
Hey Tier Tier Skilled Pandemic watchers, did you know that Bill Gates and his Scorpion predecessors and the WHO, et. al. also sent Ivermectin to Africa and other countries to be used as both a treatment and a prophylactic for River Blindness and the associated flies that cause it and I suppose other conditions?
Maybe they do love us.
Let’s look at Zika and birth defects allegedly from mosquitoes carrying a virus that Bill Gates and the United States Government and Bob Malone and Big Pharm would like to protect us from.
Zika.
Promo Code: Housatonic
In her first major address on the Zika outbreak, the head of the World Health Organization, Dr. Margaret Chan, said the mosquito-borne virus has gone from being "a mild threat to one of alarming proportions." Chan spoke Thursday in Geneva.
The apparent link between Zika and severe birth defects in children in Brazil still hasn't been definitively proven but Chan says the threat is so high that she's calling for an emergency committee to advise her on "the appropriate level of international concern and for recommended measures that should be undertaken in affected countries and elsewhere." There's no vaccine or treatment for Zika. Chan says eliminating mosquito breeding grounds is one of the most important defenses against the disease.
"We really need to concentrate on mosquito control," Chan said in a briefing to the Executive Committee of the WHO.
The Zika virus was first detected in the Americas in May 2015 in Brazil. It has since spread in Chan's words "explosively" to 22 countries and territories in the hemisphere. There have also been a handful of cases in the mainland United States, but all of those have been in people who recently returned from Zika-affected areas.
☝️
Looks like we need to study semen samples to beat this Mosquito Disease which we haven’t definitively proven causes birth defects…but hey it apparently does, y’all…and out of an *abundance of caution…
*Remind me to do a post on this clever shitfuckery.
Okay…
In the above collection of interviews, Bob Malone also discusses using anti-virals as prophylactic vaccines of a sort.
This was in 2017.
In 2020 in the How to Save the World Dark Satanic Horse Podcast, this exact same talking point came up via Steve Kirsch and Bret Weinstein.
What are the freaking odds of that?
Prophylactic use of Ivermectin could end the fake pandemic!
Jill Glasspool Malone was big mad that the USG was not helping the Malones make some more money for their clients with Zika back in 2016.
Promo Code: Charles Wright
Jill Glasspool Malone, PhD
President at The Malone Institute
Published Apr 4, 2016
Below is a list of projects from 2011-2016 that Robert Malone and I (RW Malone MD, LLC) have provided direct leadership and proposal management in. That is almost ten billion dollars in the last five years. We helped win 562 million in contract awards and nine billion in IDIQ awards. That is ten billion dollars that these companies may not have won with out involvement. That is a whole lot of really important research that wouldn't have happened if it weren't for us, particularly Robert. It is kind of mind blowing.
We are still looking for funding for our Zika clinical trials but the US Gov appears to have decided to not fund any anti-viral clinical research (and we are just about ready to go). So, I am on the hunt for our next big project. I was told by a "big" project management firm that other day, we we work for about a tenth of what they do... But our success rate is over 95%, while theirs is below 50%.
We work our asses off, we work smart, we don't really advertise, we have clients that have been with us for years and we haven't raised our rates in a decade. So, as I am completely discouraged with our government again over their response to Zika, I have to remember our wins. Because we are doing something right. We may not fund big conferences, or big dinners at awards nights but we bring in the contracts for our clients, we write solid scientific proposals that get funded and we don't brag (much)...
😐
From the WHO.
Zika virus is primarily transmitted by the bite of an infected mosquito from the Aedes genus, mainly Aedes aegypti, in tropical and subtropical regions. Aedes mosquitoes usually bite during the day, peaking during early morning and late afternoon/evening. This is the same mosquito that transmits dengue, chikungunya and yellow fever.
Zika virus is also transmitted from mother to fetus during pregnancy, through sexual contact, transfusion of blood and blood products, and organ transplantation.
Commentary: Zika Virus sounds an awful lot like AIDS.
AIDS sounded an awful lot like COVID in some other key ways.
Paging Celia. Jump on this and connect some of this. I’m drowning over here.
“Emerging”
The PR Team likes this term a lot.
It’s scary.
ex>
Ralphie Bear had been studying coronaviruses and how they induce myocarditis in bunnies going back to the '80s, (Hey, Remember the ‘80’s?!!), and securing funding because of how this translates to human hearts, and flash forwards now, 30-freaking years later, it looks like those doggone bats with their TOTALLY NATURALLY OCCURRING CORONAVIRUSES THAT SHOW POTENTIAL FOR HUMAN EMERGENCE were cropping up.
https://www.nature.com/articles/nm.3985
Zika pix from here:
https://sites.google.com/housatonicits.com/home0003/research/zika-virus-epidemic-2015-2016
Back to the WHO.
WHO declared a public health emergency of international concern regarding microcephaly, other neurological disorders and Zika virus from February to November 2016. Cases of Zika virus disease declined from 2017 onwards globally; however, Zika virus transmission persists at low levels in several countries in the Americas and in other endemic regions. To date, a total of 89 countries and territories have reported evidence of mosquito transmitted Zika virus infection, however surveillance remains limited globally.
No vaccine is yet available for the prevention or treatment of Zika virus infection. Development of a Zika vaccine remains an active area of research
The rolling crisis will always require surveillance and countermeasures (access to the bodies.)
“We would have had so much Ebola!”, cried Melinda Gates. “The world got lucky.”
Chapter Two: The Synergy of Drugs and Dual Use Research and that Mectizan Program
What can be studied to heal can also be used to harm.
What can be studied to protect can also be used to harm.
ex:
Healing or “protecting” you from the Dangerous Germs Coronavirus with emergency countermeasures such as mRNA “Vaccines” can harm you.
P-GLYCOPROTEIN
The original post that I intended to write was Ivermectin Bad.
Just kidding. 😹
OR AM I?
That was meant to be ironic simplicity.
We are going to shift gears now. Does all of this link up somewhere? I think so but I am cutting my teeth on Science Journal-Speak which if you hang out in STEMLand long enough you become a gibberish murmuring Vanden Botch predicting things and Doom Porning like Klimate Vanden Bosshes do and Wellness Vanden Bossches do about 30-40% of heavily jabbed nations perishing in two months because of this new Coronavirus Sentient Variant that do not come to pass and blathering about zeeee Sccciieeeeennncceee and Naaaturreee and Ekuuuhlllibbriuums.
But we dum-dums have to build this block by block. And one of the things that I do is cast a net and hope that the sharp detectives who didn’t spend their whole lives working for GAVI and Sanofi and Pfizer or if they did, they actually did rigorously cross examine themselves and their premises and can thus come here can fill in some blank spots.
Reviewing cancer and IVM research, I keep seeing references to P-glycoprotein.
SageBotAISummary of P-glycoprotein
P-glycoprotein is an important protein of the cell membranes that pumps many foreign substances out of cells. It exists in animals, fungi, and bacteria, and it likely evolved as a defense mechanism against harmful substances.
P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243)…
…is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent *efflux pump
*An efflux pump is an active transporter in cells that moves out unwanted material.
…with broad substrate specificity. PGP exists in animals, fungi, and bacteria, and it likely evolved as a defense mechanism against harmful substances.
P-gp is extensively distributed and expressed in the intestinal epithelium where it pumps xenobiotics (such as toxins or drugs) back into the intestinal lumen, in liver cells where it pumps them into bile ducts, in the cells of the proximal tubule of the kidney where it pumps them into urinary filtrate (in the proximal tubule), and in the capillary endothelial cells composing the blood–brain barrier and blood–testis barrier, where it pumps them back into the capillaries.
P-gp is a glycoprotein that in humans is encoded by the ABCB1 gene.[4] P-gp is a well-characterized ABC-transporter (which transports a wide variety of substrates across extra- and intracellular membranes) of the MDR/TAP subfamily.The normal excretion of xenobiotics back into the gut lumen by P-gp pharmacokinetically reduces the efficacy of some pharmaceutical drugs (which are said to be P-gp substrates). In addition, some cancer cells also express large amounts of P-gp, further amplifying that effect and rendering these cancers multidrug resistant. Many drugs inhibit P-gp, typically incidentally rather than as their main mechanism of action; some foods do as well.[6] Any such substance can sometimes be called a P-gp inhibitor.
P-gp was discovered in 1971 by Victor Ling.
PGlycoprotein discovered.
There’s a history of Globalist efforts to reduce Onchocerciasis in Africa that predates Ivermectin which I think is a relevant background to this debate. Let’s look at the Onchocerciasis Control Program which began before Merck’s Ivermectin program.
The Onchocerciasis Control Program (OCP) of the World Bank Group began in 1974.
Robert McNamara led the program for World Bank Group. Most people know McNamara’s name. From January 21, 1961 – February 29, 1968, Robert McNamara was Secretary of Defense for the United States. McNamara infamously sprayed US soldiers and the Vietnamese people with DDT during his tenure as SecDef.
Merck starts sending the Mectin down to Africa, etc. in the mid 70s.
In order to reach this goal, Merck leaders recognized that many organizations with unique skills would need to work together as a team. To enable this collaboration, Merck established the Mectizan Donation Program (MDP), a ground-breaking public-private partnership. Operating from the Atlanta-based *Task Force for Global Health, the MDP coordinates technical and operational activities between Merck, WHO, endemic countries, and a range of public and private stakeholders.
The Task Force For Global Health
Building on the successful implementation of the river blindness program, in 1998 Merck expanded its commitment to include donating Mectizan for another neglected tropical disease, lymphatic filariasis, also known as elephantiasis, in African countries and Yemen where it co-exists with river blindness. For lymphatic filariasis, Mectizan is administered with albendazole, a drug donated by GSK.
I’m sorry. (NO I’m not.)
I do not think that Big Pharm and the US Defense Dept. give a good goddamn about curing disease in foreign lands.
That is my bias and I do fight against my own biases to sort out what is real.
I am going to the animal studies almost exclusively now because they don’t have to phony their language up so much to protect their hoooman herd-culling study funders.
People want to protect their pets.
Whereas Scorpions want to kill the hoooomanz and they hire people to spin and then apparently redact statements about say, GRAPHENE OXIDE
"These nanoparticles have also been used in the fight against COVID-19."
"Graphene-based nanoparticles possess remarkable physiochemical properties, making them promising for diverse applications in biomedicine, agriculture, food, and industrial applications."
And then fend off the stans who can’t seem to grasp that this is how it gets done.
Dual use. Ostensible reason vs. Real reason.
I digress.
https://www.sciencedirect.com/science/article/abs/pii/S003452881000189X
Teratogenic and cytogenetic effects of ivermectin and its interaction with P-glycoprotein inhibitor
Abstract
Experiments in animals proved that P-glycoprotein (Pgp) forms a functional barrier between maternal and fetal blood circulation in the placenta, thus protecting the fetus from exposure to xenobiotics during pregnancy. In this study we aimed to demonstrate the effects of administration of ivermectin (anthelmentic drug, Pgp substrates), either alone or simultaneously with verapamil (Pgp inhibitor) in Wister rats on fetal development, maternal bone marrow for detection of micronuclei (MN), chromosomal aberrations and mitotic index (MI) and embryonic liver cells for cellular proliferation indicated by MI, and bleeding from umbilical vessels for detection of embryonic micronuclei (MN).
The results revealed that administration of ivermectin or verapamil at 6th through 15th day of gestation did not significantly altered fetal development. While, co-administration of ivermectin and verapamil clearly disturbed fetal development as indicated from abnormal feto-maternal attachment and a significant decrease in fetal weights and numbers. Furthermore, co-administration of both drugs induced a significant increase in resorption sites, post-implantation loss and external, visceral and skeletal abnormalities.
“co-administration”
Please remember this word.
And drop the co- and think, THEY CAN CREATE INTERACTIONS.
ESPECIALLY WITH DRUGS OR COMPOUNDS THAT HANG OUT IN THE BODY FOR A WHILE SAY ARE LIPOPHILIC WHICH MEANS THAT THEY LIKE TO HIDE OUT IN YOUR FAT CELLS.
The results revealed that administration of ivermectin or verapamil at 6th through 15th day of gestation did not significantly altered fetal development. While, co-administration of ivermectin and verapamil clearly disturbed fetal development as indicated from abnormal feto-maternal attachment and a significant decrease in fetal weights and numbers. Furthermore, co-administration of both drugs induced a significant increase in resorption sites, post-implantation loss and external, visceral and skeletal abnormalities.
Co-administration did what neither did alone, per the study.
Again, an experiment on animals, Wister Rats to be specific.
They also induced genotoxicity in both dam and embryonic cells indicated by reduced mitotic index, increased number of micronucleated erythrocytes in both, and increased different types of chromosomal aberrations in dam cells, while ivermectin alone show some genotoxic effect on somatic cells of dams and the embryos. Verapamil induced reduction of embryonic mitotic index. We concluded combined treatment of ivermectin and verapamil severely affect fetal genetic material and development and induced genotoxic effect in somatic cells of the dams.
Introduction
Therapeutic compounds cross placenta depending on their lipid solubility, molecular size, degree of ionization and plasma protein binding. This function is facilitated by various transporters that are expressed differentially in the functional unit of placenta (Ganapathy et al., 2000).
The drug-transporting P-glycoprotein (Pgp) originally discovered in multidrug resistance tumor cells (MDR) (Juliano and Ling, 1976), belongs to the superfamily of ATP binding cassette proteins.
Pgp is expressed in a variety of normal tissues mostly of epithelial origin (Thiebaut et al., 1987, Croop et al., 1989, Song et al., 1995). Pgp (the product of mdr1a gene) was demonstrated in biologically important protective barriers, blood–brain barrier, blood testis barrier, maternal fetal barrier and intestinal barrier (Croop et al., 1989, Schurr et al., 1989, Schinkel et al., 1994).
One major physiological role of drug-transporting Pgps is the protection of an organism against potentially toxic compounds that can be encountered in the environment by limiting the passage of drugs and compounds into the fetus (Smit et al., 1999). Placental Pgp can be partially or completely blocked by administration of Pgp inhibitors resulting in greatly increased transplacental passage to the embryo. Furthermore, placental Pgp tends to increase during pregnancy (Croop et al., 1989). Effectively, progesterone is a potent inhibitor of Pgp activity and its level increase with pregnancy age. Thus Pgp activity is probably strongly down modulated in mature placentas.
Commentary: Here is what I think is going to be spun out, i.e. marketed, or already is.
Ostensible vs. Real.
PgP is a barrier protector of the host.
PgP also apparently exists in Cancer Cells which become like Alien movie organisms in their own right.
“We need to bypass the PgP Cancer in the Alien to kill it.”
::whispers:: and not bypass the Goody PgP in the host because that would be bad for the host and we love the host and want to help the host with DaVinci cancer spattering devices and chemotherapy. We mean well.
Pgp substrates are usually organic molecules ranging in size from 200 Da to almost 1900 Da. Most of them are uncharged or weekly basic in nature, but some acidic compounds can also be transported (Schinkel and Jonker, 2003).
Drugs and xenobiotics that bear significant structural similarity to the physiological substrates have the potential to be recognized by the transporters expressed in the placenta (Ganapathy et al., 2000). Fetal tolerance to a certain level of maternal exposure to poor Pgp substrates will be lower than for equivalent amounts of drugs that are good Pgp substrates (Smit et al., 1999). Ivermectin (Pgp substrates), an acaricide and anthelmentic drug of the family avermectins, produced by Streptomyces avermitilis cultures, is a well tolerated drug and except for some genetically-modified animals (collie dog), no side effects in mammals at pharmacological doses were detected (Fisher and Mrozik, 1992, Mealey et al., 2001). The low ivermectin toxicity has been attributed to its restricted access to some organs and brain tissues, especially for being a substrate of Pgp (Schinkel et al., 1994).
Interactions with substances that inhibit Pgp are of great interest, as they can potentially enhance the absorption of important medicines that are generally poorly absorbed, such as chemotherapeutic medicines. Additionally, Lankas et al. (1998) provided evidence that placental Pgp may also play an important role in the protection of the developing fetus. They also showed that the placental Mdr1a (Pgp gene product) is present in the fetus-derived epithelial cells that make up the exchange border between the fetal and maternal blood circulation, and that Pgp faces the maternal blood side. It was shown that absence of Mdr1a in naturally occurring Mdr1a mutant mice is associated with enhanced sensitivity of the fetus to isomer of the pesticide avermectin. Hence, functional Mdr1a Pgp may largely limit the fetal penetration of this compound (Lankas et al., 1997, Lankas et al., 1998). They further showed that enhanced fetal drug penetration paralleled the increased avermectin sensitivity in Mdr1a Pgp mutant fetuses.
In this study we aimed to demonstrate the effects of administration of ivermectin (anthelmentic drug, Pgp substrates), either alone or simultaneously with verapamil (Pgp inhibitor) on fetal development, maternal bone marrow for detection of MN, chromosomal aberrations and cellular proliferation and embryonic liver cells for cellular proliferation, and bleeding from umbilical vessels for detection of embryonic MN.
Thank you, Animal Science. No snark.
Again, this is not a normie post.
This is not an entertaining post.
This is a non-STEM trying to grasp some broad strokes with a very cynical view of World Ivermectin Day! which is Batshit Crazy and the World has gone mad.
Thanks for reading.
If you have Deep STEM Thoughts, leave ‘em.
I'm pondering whether "Zika" was transmitted by mosquito bites or potentially by the pesticides used to eliminate said mosquitoes??? Organophosphates and Pyrethroids? Some secret military MK Naomi concoction tested in another third world country again? Just asking for a friend. LOL.
I am screaming here..my brain cannot comprehend much these past few days..but I do NOT belive the microecaphaly had anything to do with Zika....it was a toxin...or jabs for something else.....and I don't believe ivm has anything to do with anything..EXCEPT if they combine it with other drugs.....which should not be taken together....
And furthermore my taxpayer dollars is funding this crappola and I am incensed.